Te Kaihanga N-Acetyl-L-cysteine ​​pai (NACET) Kaihanga - Cofttek

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Kia 8, 2021

Ko Cofttek te kaiwhakanao paura N-Acetyl-L-cysteine ​​eter (NACET) pai rawa atu i Haina. Ko ta maatau wheketere he punaha whakahaere whakaputa (ISO9001 & ISO14001), me te kaha whakaputa 300-marama.


tūnga: I roto i te Production Production
Waea: 1kg / putea, 25kg / Taramu

N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Snga whakaritenga

ingoa: N-Acetyl-L-cysteine ​​ethyl ester (NACET)
CAS: 59587-09-6
viivii 98 orau
Tātai rāpoi: C7H13NO3S
Taumaha Molecular: 191.25 g / mol
Te Poari Maka: 197 ki 202 ° C
Ingoa matū: N-Acetyl-L-cysteine ​​etyl ester

NACET (R) -ethyl 2-acetamido-3-mercreensropanoate

taurite: N-Acetylcysteine ​​ethylester; (R) -Methyl 2-acetaMido-3-Merc2ropanoate; -Ethyl 3-acetamido-2-mercrombropanoate; Ethyl (2R) -3-Acetamido-2-Sulfanyl-Propanoate; (2R) -3-Acetamido-2-Mercrombropropanoic Acid Ethyl Ester; (2R) -3-Acetamido-XNUMX-Mercapto-Propionic Acid Ethyl Ester
KAUPAPA KI: MSMRAGNKRYVTCX-LURJTMIESA-N
Te Haurua Haurua: N / He
Haupae: He ngoikore ki te wai
Tikanga rokiroki: 0 - 4 C mo te wa poto (nga ra ki nga wiki), -20 C ranei mo te wa roa (marama)
Taupānga: N-Acetyl-L-cysteine ​​ethyl ester paura ka whakamahia hei whakanui i te mahara, arotahi, auahatanga, mohio me te hihiri.
ahua: Te paura ma-waho

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) NMR Spectrum

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) NMR Spectrum

Mena e hiahia ana koe ki te COA, MSDS, HNMR mo ia waahanga hua me etahi atu korero, tena koa whakapiri mai ki a maatau kaiwhakahaere hokohoko.

 

He aha te N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)?

Ko te N-Acetyl-L-cysteine ​​ethyl ester puehu he mea noa, he waihanga ranei hei whakarei ake i te mahi roro, hei whakapai ake i te mahi hinengaro ki nga taangata hauora. Ko te nuinga o nga wa e mohiotia ana ko Nootropics me nga raau taero atamai, kua rongonui ratou i roto i te hapori tino whakataetae o enei ra ka kaha ki te whakanui i te mahara, te aro, te auaha, te mohio me te hihiri.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) painga

Ko te esterification o te roopu carboxyl ki te whakaputa i te N-acetylcysteine ​​ethyl ester ka whakapiki i te ngutu o te NAC me te tino whakapai ake i ana rongoa rongoa rongoa. He nui te koiora o te NACET (tata ki te 60%) i te NAC. Ka tere haere te NACET ki roto i nga puoro, ka mau, ka huri hei NAC me Cysteine. Kei te kitea te NACET i roto i nga ruma o nga momo kiko, tae atu ki te roro na te mea ka kaha ki te whiti i te aarai toto-roro. Kei te NACET ano hoki te whakarato i nga momo aweawewe antioxidant paruru. Ka taea te tango waha i te NACET ka awhina i te glutathione. Ka taea te kohikohi i roto i te erythrocytes a te tangata. Ka noho pea te NACET hei kaitiaki kaha mo te kino o te okawa hydroperoxide-induced He pai te koiora o te NACA i te NAC tae atu ki te rāpoi ngota hei whakapai ake i te manawanui me te wa noho o te koiora me te koiora.

 

Hauora

Ko te N-Acetyl-L-cysteine ​​ethyl ester puehu 59587-09-6, he mea noa, he waihanga ranei hei whakarei ake i te mahi roro, hei whakapai ake i te mahinga hinengaro. I te nuinga o te wa e mohiotia ana ko Nootropics me nga raau taero atamai, kua rongonui ratou i roto i te hapori tino whakataetae o enei ra ka whakamahia hei whakanui i te maumahara, te arotahi, te auaha, te mohio me te hihiri.

Ka whakapiki ake te NACET i te hauwai hauwai (H (2) S), hei tohu mo te kaitono pai mo te whakamahi a-waha hei kaiwhakanao H (2) S, me nga painga tino nui atu i te NAC.

I muri i te maimoatanga a-waha, i taea e te NACET (engari kaore i te NAC) te whakanui ake i te kiko o te GSH o te nuinga o nga kiko i roto i te kiore (tae atu ki te roro), i tiakina mai i te haurangi paracetamol.

 

Hauora Hauora

Ko te rangahau nui tuatahi e whakaatu ana ko te taapiringa o te kai me te N-acetylcysteine ​​kaha (NAC) kaha ki te aukati i te tukurua o te RNA me te whakaiti i te kaha o nga mate e pa ana.

Ma tenei whakarereketanga o te NAC e ahei ai te whakamarumaru i o punetoto toto mai i te kino o te waikura, na reira ka taea e te punaha aarai tinana o to tinana te tiaki i to tinana mai i nga tupapaku o COVID-19 (Ehara tenei i te tohutohu rongoa). Ko te NAC ano he iti te koiora-a-waha na te mea ka tere te pehanga i roto i to ate i mua i te taenga atu ki o kiko, ina koa ko te epithelium pūkahukahu e tupono ana ki te kino o te kohinga COVID-19.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) whakamahinga?

Kaore i roa i whakamatauhia nga whakamatautau haumanu nui ki te whakaū i nga hua o te N-acetylcysteine ​​(NAC) hei aukati i nga mate e pa ana ki te ahotea Ko tenei pea ka pa ki tona koiora iti. I whakaaro matou ko te whakatau tata i te roopu carcaryl o NAC hei whakaputa N-acetylcysteine ​​ethyl ester (NACET) ka kaha te whakanui i te lipophilicity o NAC, na reira ka pai ake te whakapai ake i tana pharmacokinetics. I nga mahi o tenei wa, ka korerohia e matou te paanga matū, te rongoa rongoa me te anti-oxidant o te NACET, ina koa ko nga tohu NACET. I kitea e maatau te tere o te NACET i nga kiore i muri i te whakahaere a waha engari ka whakaheke noa i te plasma. Na te mea he ahuatanga motuhake o te NACET: ka uru wawe ki roto i nga punaha i te wa e mau ai te huri ki te NAC me te cysteine. I muri i te rongoa a-waha, i taea e te NACET (engari kaore ko te NAC) te whakapiki ake i te kiko o te kakano o te nuinga o nga kopa i tirotirohia, ka whakauruhia te roro, me te tiaki mai i te haurangi paracetamol i te kiore. Kei te NACET hoki te waahanga ahurei hei whakaemi i roto i nga erythrocytes tangata kei reira e whai mana ana hei kaiwhakaaro kaha ki te kino o te whakahiato oxideroxide-induced. Ko ta maatau rangahau e whakaatu ana na te kaha ki te uru ki nga puoro me te whakaputa i te NAC me te cysteine, ka piki te NACET ki te huri i te hydrogen sulfide (H (2) S), na reira e tohu ana i tetahi kaitono pai mo te whakamahinga a-waha hei kaiwhakanao H (2) S, me nga hua pai i runga i te NAC. Kei te pea te NACET ki te whakakapi i te NAC hei kaihoko a mucolytic, hei rongoa paracetamol me te antioxidant e pa ana ki te GSH.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) Taupānga

Ko te NACET (N-Acetylcysteine ​​ethyl ester) he taaputa puoro-kiri-ngongo-puoro-kiri ka kitea he waahanga pharmacokinetic rereke me te kaha antioxidant tino. He nui te koiora i te NACET. He antioxidant kaha me te whai kiko o te GSH, e pa ana ki tana waikawa kore-Nety-acetyl -L e rereke ana i te -cysteine ​​(NAC). Ko te NACET te paura ma i te pāmahana rūma me te takahi noa i te wai me nga whakarewa o te kaiao.

Ko te NAC tetahi takenga o te hurihuri. Mai i te 1970, kua whakamahia ki te hamani i nga turoro me te mate nui o te acetaminophen me nga mate neurological, ka hokona ana hei rongoa me te taapiringa kai. Kua whakaritea ki te NAC, he nui ake te lipophilicity me te kounga rongoa rongoa whakateatanga. Kei te kaha ki te whakakapi i te NAC pharmacological, ano he kaihoko mucolytic, antioxidant, kaiwhakarato o GSH, paracetamol antidote, a ko te kaituku takoha o te kaituku gateous H 2 S me te kaiwhakaora tiaki UV.

I tua atu, ko te kaha o te nucleophilicity me te whakaheke i te kaha o te NACET kua kitea ano hoki i roto i nga pūtau toto whero a te tangata. Kua kitea ko te kohi i roto i nga pūtau toto whero a te tangata, te aukati i te kino o te waikawa e whakahekehia ana e te hydroperoxides. No reira, ko te kaha o te NACET hei mahi anti-nitrite-whakaheke kaha, he nui ake i te methemoglobinemia NAC me etahi atu oxidants kaha. Ko nga rangahau i nga kiore kua kitea ko te NACET te tere tere atu i te NAC i te wa e whakahaerehia ana te NACET. Ka taea te whakauru ki nga puoro me te whakaputa i te NAC me te cysteine, e kaha ana ki te whakanui i te hauwai hauwai (H (2) S) i roto i te tohanga. He kaitono pai mo te whakamahi a-waha hei kaiwhakanao H (2) S,

 

NGAIANGA paura mō te hoko(Te wahi hei hoko i te paura NACET i te nuinga)

He pai ki ta maatau kamupene nga hononga roa me o taatau kiritaki na te mea e arotahi ana ki nga ratonga kiritaki me te whakarato hua nui. Mena kei te aro atu koe ki o maatau hua, he ngawari o taatau ki te whakarite i nga ota ka uru atu ki o hiahia motuhake, me to maatau tere tere mo nga whakahau ka haangai koe ki te whakamatau i a maatau hua i runga i te waa. Ka aro nui a matou ki nga ratonga taapiri. E waatea ana mo nga patai ratonga me nga korero hei tautoko i to umanga.

He kaiwhakarato paura NACET ngaio matou mo etahi tau, ka whakawhiwhia e matou nga hua ki te utu whakataetae, a, ko te hua e tino kounga ana, me te whai i nga whakamatautau tuuturu, motuhake hoki hei whakarite kia haumaru mo te kohi huri noa i te ao.

 

Tohutoro

[1] N-acetylcysteine ​​ethyl ester hei whakarei GSH i roto i nga pūtau endothelial tuatahi a te tangata: He rangahau whakarite me etahi atu raau taero. 2018 Oketopa; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[2] N-acetylcysteine ​​ethyl ester hei whakarei GSH i roto i nga pūtau endothelial tuatahi a te tangata: He rangahau whakarite me etahi atu raau taero. 2018 Oketopa; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[3] S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) me te N-acetyl-L-cysteine ​​ethyl ester (NACET) -Nga kaitono rongoa a-koiora me nga tohu rongoa rongoa motuhake hei whakamahi waha hei KORE, H2S me te GSH kaiwhakarato me hei antioxidants: Nga hua me te tirohanga nui. 2018 Pepuere; 8 (1): 1-9. mahi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Tihema 13. Arotake. PMID: 29568662.